Misuse and over-reliance are both risks, but they are not the same, IMHO.
Over-reliance is not accounting for the risks of erroneous conclusions, given proper use of the models. That is the risk resulting from the fact that every model is just an approximation of the "the real world."
Misuse, on the other hand, is using a model, not as it was intended.
For instance, the recently prevailing assumption that the real estate prices were to go up, indefinitely, was an example of a misuse of statistical analysis. The statistical insignificance of observing the process for only a couple of decades constitutes the improper use of statistical analysis, given the prior knowledge of cyclical nature of economic process (to say the least.)
This, in turn, empirically supported the hypothesis that creditworthiness of borrowers was not very relevant in assessing the risks embedded in RMBS and related structures. The same assumption was being made by the rating agencies in assigning ratings, which resulted in misuse of other models.
That is, statistically insignificant series of observations of real estate prices led to using erroneous inputs into various models. This amounted to the misuse of statistical analysis and resulted into misuse of other models.
The use of statistics for the purpose of selling an "alternative" approach to measuring risk to the financial industry, which was based on disregarding cyclical nature of economic process, but concentrated on very insignificant series of observations, was a misuse, in my opinion.
The cyclical nature of economic process has been observed for centuries, and, as such, presents an assumption of a much stronger statistical significance than that of real estate prices going up indefinitely based on a couple of decades worth of observations.
Statistics is used to separate significant from insignificant (relative to the context of a study/method.) Trying to push an insignificant set of facts, as the basis for a conclusion that helps achieve an ideological objective of "American Dream" (a house for everybody) plus fame and recognition for those who pushed the idea, is not, principally different from some more subtle instances of misuses of scientific methods my Marx, Trozky, at al.
Over-reliance on models/methods is, in fact, a form of misuse (in the most general sense of the term "misuse").
Although, the usage of the terms in this context can be compared with the usage of the terms over-reliance on funding, and misuse of funding. There should be a way to differentiate between the two.
One is not knowing/accounting for the limitations of the approach in a particular context, while the other is using the object of the expression (be that funding or models/methods) for the purposes, for which it was not intended.
On the other hand, if "misuse" is too generic a concept, what would be the name for the types of misuses that are not over-reliance?
What would you say about plugging the assumption (and derivations thereof) that real estate prices would go infinitely up into any model? The model stays the same, whether you do that or not. How is that the model's fault? Is this misuse or over-reliance?